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Ranitidine-associated CNS-ADRs,particularly lethargy,confusion,somnolence, and disorientation,occurred more frequently in patients with renal function impairment,and these were associated with higher peak concentrations,average plasma concentrations,and area under the curve. Ranitidine,when given in conventional doses,can cause CNS-ADRs, particularly in older patients who have substantial renal function impairment.These CNS-ADRs occur as a consequence of altered ranitidine disposition.Ranitidine doses should be reduced when renal function impairment is present,and patients should be carefully observed for CNS- ADRs. |
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